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Letter to the editor: Effect of exercise training on modulating the TH17/TREG imbalance in individuals with severe COPD: A randomised controlled trial.

PubMed / Pulmonology · 2026-01-22 · By Thakur A, Bhatia K, Vaid N · Pulmonology

A letter to the editor published in Pulmonology presents findings from a randomized controlled trial examining how exercise training affects the TH17/TREG immune cell imbalance in people with severe COPD. Dysregulation between these T-helper and regulatory T-cell populations is associated with chronic airway inflammation in the disease. The study suggests exercise-based intervention may help modulate this immunological imbalance, with potential implications for PT-led pulmonary rehabilitation programs.

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