Electroacupuncture modulates P300-mediated STAT6/PPARγ binding to promote M2 polarization of microglia following cerebral ischemic injury.

A study published in International Immunopharmacology investigated how electroacupuncture influences microglial behavior after cerebral ischemic injury. Researchers found that electroacupuncture promotes the shift of microglia toward the anti-inflammatory M2 phenotype by modulating the P300-mediated interaction between STAT6 and PPARγ signaling pathways. These findings suggest a potential molecular mechanism by which electroacupuncture may support neuroprotection and recovery following stroke.

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