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Functional Connectivity Alterations of the Central Autonomic Network in Multiple Sclerosis: Links to Fatigue and Aerobic Training Effects.

PubMed / Neurol Neuroimmunol Neuroinflamm · 2026-05-11 · By Guido G, Valsasina P, Morozumi T, et al. · Neurology(R) neuroimmunology & neuroinflammation

A study published in Neurology Neuroimmunology & Neuroinflammation examined how functional connectivity within the central autonomic network (CAN) is altered in people with multiple sclerosis and how these changes relate to fatigue. Researchers also investigated whether aerobic exercise training produces measurable effects on CAN connectivity. The findings are relevant to physical therapists designing and justifying aerobic rehabilitation programs for MS patients, particularly those experiencing fatigue.

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