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A tailored cognitive behavioural therapy intervention for depression in those newly diagnosed with multiple sclerosis (ACTION-MS): A randomised, assessor-blinded, active comparator trial.

PubMed / J Affect Disord · 2026-05-13 · By Kiropoulos LA, Kilpatrick TJ, Kalincik T, et al. · Journal of affective disorders

A randomized controlled trial examined a tailored cognitive behavioural therapy (CBT) program designed specifically for depression in people newly diagnosed with multiple sclerosis (MS). The ACTION-MS trial used an active comparator design with blinded assessors to evaluate this targeted psychological intervention. Findings from this study may inform mental health support approaches within multidisciplinary MS care teams, including physical therapists who routinely work with this population.

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