FREquency of strength home exercises for knee osteoarthritis pain: Protocol for the FRESH non-inferiority randomised controlled trial.

The FRESH trial is a non-inferiority randomized controlled trial investigating whether performing home-based strengthening exercises less frequently produces comparable pain relief to a higher-frequency regimen for individuals with knee osteoarthritis. The protocol aims to determine the minimum effective exercise dose, which could have practical implications for patient adherence and home exercise program design in PT practice. Results may inform how clinicians prescribe unsupervised strengthening routines for this common musculoskeletal condition.

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