Effects of serotonergic pharmacological manipulation on exercise performance and central fatigue: a systematic review and three-level meta-analysis.
A systematic review and three-level meta-analysis examined how pharmacological manipulation of the serotonergic system influences exercise performance and central fatigue. Researchers analyzed studies involving drugs that alter serotonin activity, assessing their effects on endurance capacity and perceived exertion during physical tasks. The findings contribute to understanding the neurochemical basis of central fatigue, which has implications for rehabilitation professionals managing patients with exercise intolerance or fatigue-related conditions.
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