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Research PubMed / Brain Inj clinical-researchneurological-rehabbrain-injury

Using intrathecal baclofen for effective management of paroxysmal sympathetic hyperactivity secondary to cerebral fat emboli syndrome: a case report.

PubMed / Brain Inj · 2026-07-18 · By Andary M, Bertagnolli H, Costeas A, et al. · Brain injury

This case report documents the successful use of intrathecal baclofen (ITB) to control paroxysmal sympathetic hyperactivity (PSH) arising from cerebral fat emboli syndrome, a rare and challenging condition. The authors describe how ITB therapy provided effective symptom management when other interventions were insufficient. Physical therapists working in brain injury rehabilitation may encounter PSH and should understand emerging pharmacological strategies that influence patient tolerance for therapy.

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